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Rafat Siddiqui

Siddiqui, Rafat, PhD

Food Sciences

Associate Professor

Phone: 804-524-5957
Fax: 804-524-5186

Siddiqui, Dr. Rafat, PhD


Agricultural Research Station

Associate Professor

Phone: 804-524-5957
Fax: 804-524-5186


  • Post-Doc (1990) - Vanderbilt University, Nashville, TN, USA
  • Post Doc (1989) - Massey University, Palmerston North, New Zealand
  • Ph.D. (1988) - Australian National University, Canberra, Australia
  • M.Sc. (1982) - University of Karachi, Karachi, Pakistan

Research Interest

  • Lipids in health and disease
  • Nutraceuticals for anti-inflammatory, anti-cancer, anti-diabetic properties
  • Nutrients for improving muscle growth
  • Super Foods (Papaya, Turmeric, Plums, Grapes)

Professional Society Memberships 

  • International Society for the Study of Fatty acids and Lipids (ISSFAL)
  •  American Nutrition Society (ANS)
  • The Nutrition Society (UK)


  1. Asian Journal of Biochemistry 
  2. American Journal of Biochemistry and Molecular Biology
  3. Bioenergatics
  4. British Journal of Nutrition
  5. Enliven: Challenges in Cancer Detection and Therapy
  6. Life Science Global
  7. Journal of Biology and Nature
  8. Journal of Biological Sciences
  9. Journal of Cancer Metastasis and Treatment
  10. Journal of Food and Nutrition
  11. Journal of Glycomics and Lipidomics 
  12. Journal of Modern Chemistry and Applications
  13. Journal of Molecular and Genetic Medicine 
  14. Journal of Nutrition Sciences
  15. International Achieves of Clinical Pharmacology
  16. International Journal of Biological Chemistry
  17. Nutrition Health and Food Engineering
  18. Research Journal of Developmental Biology
  19. WebMedCentral


Selected Publications

  • Siddiqui, RA. Green Papaya as a Potential Source for Diabetic and Diabetic-Wound Healing Therapy. J Nutr Health Food Eng. 2016, 4(5): 00146
  • Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA (2016) Distribution of tocopherols and tocotrienols in guinea pig tissues following parenteral lipid emulsion infusion. J Parenter Enteral Nutr. 40(5): 672-681.
  • Khan MA, Mesaik, MA, Abdalla, OM, Rahim F, Samreen S, Halim SA, Mustafa G, Ambreen N, Khalid AS, Taha M, Perveen S, Alam MT, Hameed A, Haq Z-U, Ullah H, Rehman Z-U, Siddiqui RA, Voelter W. (2016) The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies. BioOrganic Chem 64: 21-28.
  • Siddiqui RA, Xu Z, Harvey K, Pavlina T, Becker M, Zaloga G, (2015) Comparative Study of the Modulation of Fructose/Sucrose-Induced Hepatic Steatosis by Mixed Lipid Formulations Varying in Unsaturated Fatty Acid Content. Nutrition and Metabolism. 12:41, DOI 10.1186/s12986-015-0038-x
  • Harvey K, Xu Z, M. Saaddatzadeh MR, Wang H, Pollok K,  Cohen-Gadol AA, and Siddiqui RA (2015) Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. Journal of Neurosurgery. 122(3): 547-550.
  • Harvey KA, Xu Z, , Pavlina TM, Zaloga GP, Siddiqui RA (2015) Modulation of endothelial cell integrity and inflammatory activation by commercial lipid emulsions. Lipids in Health and Disease 14:9 DOI 10.1186/s12944-015-0005-6
  • Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA (2015) Distribution of tocopherols and tocotrienols in guinea pig tissues following parenteral lipid emulsion infusion. J Parenter Enteral Nutr. In press.
  • Xu Z, Harvey K, Pavlina TM, Zaloga GP, Siddiqui RA (2015) Tocopherol and tocotrienol homologs in parenteral lipid emulsions. European Journal of Lipid Science and Technology. 117 (1): 15-22.
  • Harvey K, Xu Z, Walker C, Pavlina T, McGrath S, Zaloga G, Siddiqui R (2014) Parenteral lipid emulsions in guinea pigs differentially influence plasma and tissue levels of fatty acids, squalene, cholesterol, and phytosterols. Lipids. 49: 777-793.
  • Siddiqui RA, Harvey KA, Walker C, Altenburg J, Xu Z, Terry C, Camarillo I, Jones-Hall Y, Mariash C (2013) Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. BMC Cancer 13: 418.
  • Altenburg JD, Bieberich AA, Terry C, Harvey KA, Vanhorn JF, Xu Z, Jo Davisson V, Siddiqui RA (2011) A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. BMC Cancer 11: 149
  • Siddiqui RA, Hassan S, Harvey KA, Rasool T, Das T, Mukerji P, DeMichele S (2009) Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice. Br J Nutr 102: 967-975.
  • Siddiqui RA, Harvey KA, Ruzmetov N, Miller SJ, Zaloga GP (2009) n-3 fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death. Br J Nutr 102: 1811-1819.


Clinical and Translation Sciences Institute, Indianapolis, IN                08/01/13 - 06/30/15

Role of docosahexaenoic acid levels in brain tumor development

Role: PI

Abbott Nutrition                                                           01/01/09 - 12/31/13

Columbus, OH

An in vitro evaluation of the efficacy of dietary ingredients for the stimulation of muscle protein synthesis in C2C12 myocytes

Role: PI

Baxter Nutrition                                                              04/01/08 - 02/30/13

Deerfield, IL

Lipid based therapies for chronic diseases

Role: PI

Abbott Cardiovascular                                         01/01/09 - 09/30/11

Abbott Park, IL

Niacin-induced flushing response in the Langerhans cells

Role: PI

NIH, National Cancer Institute                                       7/08/09 - 07/07/11

Synergism between omega-3 fatty acids and curcumin for anticancer activities in breast cancer


Role: PI

Abbott Pharmaceuticals                                  05/01/04 - 06/30/07

(Ross Health Products) Columbus, OH

Natural products for anti-proteolysis activities

Role: PI

National Institute of Health (NIH)                                 02/01/98 - 01/30/01

Bethesda, MD

Molecular regulation of endothelial cell permeability (PO1 HL58064-01)

Role: Co-investigator     PI: English

National Institute of Health (NIH)                                08/01/98 - 07/30/99

Bethesda, MD

Docosahexaenoic acid effects on Jurkat leukemic cells RO1 CA57212

Role: Co-investigator     PIs: Jenski, Stillwell, Siddiqui           

American Heart Association                          07/01/97 - 06/30/99

Interleukin-8 Synthesis by Migrating Leukocytes (INN-97-218-GIR)

Role: PI

American Heart Association                       07/01/94 - 06/30/96

Juxtacine Regulation of Neutrophil-Endothelial Interactions


Role: PI

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